A Pharmacogenetics Kit for ARV Treatment Optimisation

DNA Strand

A Pharmacogenetics Kit for ARV Treatment Optimisation

 

SUMMARY
The African Institute of Biomedical Science and Technology (AiBST) in Zimbabwe in partnership with the University of Cape Town is developing and commercialising a pharmacogenetic diagnostic test and dosing algorithm for the safe use of the anti-retroviral drug, Efavirenz. The project will conduct a clinical validation study and a cost effectiveness/benefit analysis (CE/BA) to demonstrate the cost savings in the treatment of immunodeficiency virus infection and acquired immune deficiency syndrome (HIV/AIDS) patients with this genetic test and dosing algorithm. This demonstrates one of the mechanisms of using precision medicine in the public healthcare system.

PROGRESS
• To date the project team has finalized the development of a prototype that has been validated across several platforms and has trademarked the GeneDose name for this and future products in the pipeline.
• The team is currently running a clinical trial in Chitungwiza (5 Clinical Sites) and providing pharmacogenetics services at UCT & AiBST Harare to explain incidences of EFV related side effects in patients on ART.

OUTCOME AND IMPACT
It is expected that by providing the right dosage for all patients currently on the Efavirenz drug (estimated at over 3.5 million patients in Zimbabwe and South Africa alone), their quality of life will be improved. Studies show that of the patients on Efavirenz in Zimbabwe and South Africa, over 700 000 require dose adjustment based on this genetic status and the Genedose Efavirenz kit developed will assist in ensuring that these patients are provided with the right dosages.

 

TEAM

Prof. Collen Masimirembwa
Team Leader and Principal Investigator – Zimbabwe
African Institute of Biomedical Science and Technology (AiBST)
collen.masimirembwa@aibst.com

Prof. Collet Dandara
Deputy Team Leader – South Africa
University of Cape Town
collet.dandara@uct.ac.za

Ms Lizzie Nyamweda
Business Consultant – Zimbabwe
Primergy Investments
sales@primergy.co.zw

Dr Justen Manasa
Team Leader Diagnostics – Zimbabwe
African Institute of Biomedical Science and
Technology (AiBST)
jmanasa@gmail.com

Ms Loise Dube
Project Manager – Zimbabwe
African Institute of Biomedical Science and
Technology (AiBST)
loise.dube@aibst.com

 

Project Type

Seed project

Countries involved

Status

Ongoing